H​PLC ​Troubleshooting and Maintenance Techniques Date​

Date: Wednesday, June 16, 2021​​

Time(s): 7:00 a.m. CDT;​1:00 p.m. CDT; 8:00 p.m. CDT

Spe​aker: Todd Anderson, Global Chromatography Specialist, Teledyne ISCO


Peaks not coming out where they used to? Not as big as they usually are and don’t look the way they should? These are the clear indicators that something in the method or its execution is off. In this webinar Todd Anderson, Global Chromatography Specialist, Teledyne ISCO, will walk you through the most effective troubleshooting techniques chromatographers use to isolate problems in their systems. He will also discuss proven injection and loading techniques and other best practices for optimizing chromatographic results. And for your longer term success Todd will also address important method development factors geared to extending the life of your column.

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  • Recognizing problem indicators
  • Troubleshooting HPLC methods and procedures
  • Pump head problems and associated symptoms
  • Detector and flow cell issues and corrective actions
  • Sample injection problems
  • Loading conditions to improve peak shape
  • Sample injection techniques to help prevent blockages
  • Tuning your methods to extend column life


From this 45-minute presentation plus interactive Q&A session, attendees will learn to spot common problems earlier and become faster and more confident in troubleshooting them. Labs will save time, money, and trouble by avoiding issues that cause columns to fail prematurely. Also learn how to access Teledyne ISCO chromatography specialists at any time to assist with your prep HPLC applications.​


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Re​​verse Phase Flash Method Development Made Easy

Date: Wednesday, July 21, 2021​

Time(s): 7:00 a.m. CDT; 1:​00 p.m. CDT; 8:00 p.m. CDT

Speaker:  ​Jack Silver, Applications Chemist, Teledyne ISCO​


Reverse phase flash chromatography is more challenging than normal phase. Although reverse phase flash methods can be created from thin layer chromatography, the TLC plates may take a very long time to run, especially when using highly-aqueous mobile phases. In this webinar, Jack Silver, Applications Chemist, will explain how to avoid this problem by using analytical HPLC systems instead to create reverse-phase flash chromatography methods.

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  • Little-known secrets of scale-up from HPLC to flash
  • Why matching column chemistries is an essential factor for successful method transfer
  • Flash method development tips and tricks
  • Calculating flash methods directly from HPLC
  • How to know when prep LC will be needed to purify a compound
  • Troubleshooting your reverse-phase flash method development

F​rom this 45-minute presentation plus interactive Q&A session, attendees will understand the most important issues impacting reverse-phase flash method development and how to resolve them quickly and effectively using the latest tools and best practices.​




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Chromatography Webinar​

HPLC Troubleshooting and Maintenance

December 2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will learn to spot common problems earlier and become faster and more confident in troubleshooting them. Labs will save time, money, and trouble by avoiding issues that cause columns to fail prematurely. Also learn how to access Teledyne ISCO chromatography specialists at any time to assist with your prep HPLC applications.

Speaker: Todd Anderson, Global Chromatography Specialist, Teledyne ISCO

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Chromatography Webinar

Purification and Isolation of Cannabinoids Other than CBD from Hemp

September 2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will understand the most important issues impacting reverse-phase flash method development and how to resolve them quickly and effectively using the latest tools and best practices. ​​

Speaker: Bryan Corey, Director of Science, Lab Society​

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Chromatography Webinar​

Reverse Phase Flash Method Development Made Easy

July 2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will understand the most important issues impacting reverse-phase flash method development and how to resolve them quickly and effectively using the latest tools and best practices. ​​

Speaker:Jack Silver, Applications Chemist​

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Chromatography Webinar​

HPLC Troubleshooting and Maintenance Techniques

June 2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will learn to spot common problems earlier and become faster and more confident in troubleshooting them. Labs will save time, money, and trouble by avoiding issues that cause colu​​mns to fail prematurely. Also learn how to access Teledyne ISCO chromatography specialists at any time to assist with your prep HPLC applications.​​

Speaker​: Todd Anderson, Global Chromatography Specialist, Teledyne ISCO​

Watch the Webinar

Chromatography Webinar​

Prep HPLC Simplified ​​

May ​2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will learn to quickly identify the most important factors in prep HPLC method development and use them to more rapidly isolate target compounds with higher purity and greater yields.​​​

Speaker​: Todd Anderson, Global Chromatography Specialist, Teledyne ISCO​

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Chromatography Webinar

Easy Prep Gradients from Analytical Runs​

April ​2021: ​From this 45-minute presentation plus interactive Q&A session, attendees will learn a variety of proven techniques for developing preparative chromatography methods, and best practices for focused gradient methods to purify target compounds quickly and more efficiently.​​

Speaker​: Jack Silver, ​Application Chemist 

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Chromatography Webinar

Discovery and Optimization of New Anti-migraine Peptides

April 2021: From this 45-minute presentation plus interactive Q&A session, attendees will gain stronger insight into the role of small protein molecules, how to better purify them with reverse phase flash chromatography methods, and how to quickly solve the most common method development problems.​

Speaker(s): Dr. Christopher R. Coxon, Institute of Chemical Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK; Josh Lovell, Applications Specialist at Teledyne ISCO

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Chromatography Webinar

Large-Scale Flash Sepa​rations: Sample Loading, Method Development and Scalability Issues

March 2021: From this 45-minute presentation plus interactive Q&A session, attendees will gain greater insight into the critical factors impacting large-scale flash purifications and how to significantly reduce costs as scale increases​

Speaker: Josh Lovell, Applications Specialist, Teledyne ISCO​

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Chromatography Webinar

Flash Method Development on TLC Plates

February 2021: In this beginner-to-intermediate-level webinar, Jack Silver, Applications Chemist, describes proven procedures for using TLC results to develop flash chromatography methods.

Speaker: Jack Silver, Application Specialist

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Chromatography Webinar

Improving Prep HPLC

January 2021: In this webinar, Josh Lovell, Application Specialist, outlines the most important factors to consider in developing preparative LC methods.

Speaker: Josh Lovell, Application Specialist

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Chromatography Webinar

Introductio​n into Flash Chromatography

December 2020: In this webinar, Teledyne ISCO Application Chemist Josh Lovell gives us insight into flash chromatography, the similarities and differences of flash and HPLC and the benefits of automated flash chromatography.

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Speaker: Josh Lovell, Application Specialist

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Chromatography Webinar

Basics of Preparative Chromatography

November 2020: In our Chromatography webinar "Basics of Prep HPLC," we will discuss what Liquid Chromatography and HPLC are, the differences between analytical and prep, and the basic method development of isocratic vs. gradient. Other important topics to be covered include: effects of buffering and buffer choice for purification; injection solvent effects and solvent choices; solvent grade for prep and solvent selection; column care; and common troubleshooting techniques.

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Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​

Sample Loading Techniques for Flash and Prep HPLC

October 2020: The choice of liquid vs. solid sample loading can have a significant impact on flash and prep chromatography results. Understanding the differences in peak resolution and separation speed is critical to knowing when to apply each. In this webinar Josh Lovell, Chromatography Applications Specialist, discusses the key factors to consider as illustrated by example chromatograms.

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Speaker: Josh Lovell, Application Specialist

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Chromatography Webinar​

Managing Detection Parameters for Improved Peak Detection​

Septembe​​r 2020: In this intermediate-to-advanced webinar Jack Silver discusses how and when to use All-Wavelength Collection, baseline correction, and ESLD temperature settings to solve difficult applications.
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Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​

Prep HPLC and Column Choice Overload

July 2020: In this novice-to-intermediate-level webinar, Todd Anderson, Global Chromatography Specialist, explains his proven, easy-to-use process for column selection developed during 20 years of working with Prep HPLC applications in laboratories around the world.
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Speaker: Todd Anderson, Global Chromatography Specialist

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Chromatography Webinar​

Why TFA Alone Is Not Enough for Preparative LC​

June 2020: In this intermediate-level webinar Teledyne ISCO Applications Chemist Jack Silver explains the impact of triflouroacetic acid on preparative LC separations and why it is not an optimum solution in some applications. Alternative methods for controlling pH to improve separations are discussed.​
​

Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​

Peptides in a Flash

June 2020: In this intermediate-to-advanced webinar Jack Silver shares a wealth of practical insights developed over 30 years of experience with peptide purification applications in a broad range of time-and-cost-sensitive environments.​

Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​  

Improving Prep HPLC

May 2020: In this webinar, designed for all Chromatography scientists, Teledyne ISCO Application Chemist, Josh Lovell gives us insight into Prep HPLC, the options available to you, some challenges you could face, and troubleshooting techniques to overcome those challenges.

Speaker: Josh Lovell, Application Specialist

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Chromatography Webinar​  

Chromatography Troubleshooting


May 2020: In this webinar, designed for all Chromatography scientists, Jack Silver, Teledyne ISCO Application Chemist, focuses on basic troubleshooting methods that are applicable to all Prep Chromatography systems.

Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​  

Green Solutions for Flash and Prep Chromatography


April 2020: Teledyne ISCO Application Chemist, Josh Lovell explains that the right system, with green choices during method development, save solvent and allow you to focus on other matters in the laboratory.

Speaker: Josh Lovell, Application Specialist

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Chromatography Webinar​  

Pe​ptide Purification Overview


March 2020: Application Chemist at Teledyne ISCO, Jack Silver shows us how we can save time and money and get a high-quality purification.

Speaker: Jack Silver, Application Specialist

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Chromatography Webinar​  

Mass Directed Purification​


February 2020: In this webinar, Global Chromatography Specialist at Teledyne ISCO, Todd Anderson shows us how a mass directed auto purification system works and how the range of detection methods work together to ensure you don’t ‘come up empty’ on your purification.

Speaker: Todd Anderson, Global Chromatography Specialist

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Chromatography Webinar​  

Chromatography Theory and Method Development


January 2020: In this webinar, Teledyne ISCO Application Chemist, Josh Lovell gives us insight into Prep HPLC, the options available to you, some challenges you could face, and troubleshooting techniques to overcome those challenges.

Speaker: Josh Lovell, Application Chemist​

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Chromatography Webinar​  

​​​Introduction to Flash Chromatography


December 2019: In this webinar, Teledyne ISCO Application Chemist Josh Lovell gives us insight into flash chromatography, the similarities and differences of flash and HPLC and the benefits of automated flash chromatography.

Speaker: Josh Lovell, Application Chemist​

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Chromatography Webinar​  

​​​Sample Loading and Preparation Techniques


November 2019: Global Chromatography Specialist with Teledyne ISCO, Todd Anderson explains how with the right knowledge and equipment you can optimize efficiency, meet your purity needs and minimize sample loss and down time - saving both time and resources.​
​

Speaker: Todd Anderson, Global Chromatography Specialist

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Chromatography Webinar  

​​​Focused Gradient Generator


September 2019: In this webinar Jack Silver, Application Chemist at Teledyne ISCO will explain how gradient calculations can save time, trouble and solvents, all while improving your chromatography, but there are limitations to the gradient calculation methods. Jack Silver will also introduce us to a new gradient calculation method and explain how to apply it to your projects.
​

Speaker: Jack Silver, Application Chemist​

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Chromatography Webinar  

​​​Peptide Techniques for Prep HPLC


August 2019: Purifying your own peptides can save you time and money. Vendors can send unrefined and costly peptides in a matter of days, but 99% pure peptides can take a month or longer to be delivered. Using Teledyne ISCO​'s Flash Chromatography you can cut costs from your budget and cut weeks from achieving your objective. 

Speaker: Jack Silver, Application Chemist​

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Chromatography Webinar  

​​​Green Solvent Solutions for Flash Chromatography


June 2019: In this webinar, we will discuss "Green" chemistry in the context of developing methods including importance of stationary phase choice, alternate green solvent choices, and getting things right the first time. Finally, we will show examples of some of the system features on the NextGen and how you can use them to minimize environmental impact while maximizing purification efficiency.​ 

Speaker: Joshua Lovell, Application Chemist​

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Chromatography Webinar  

​​​Automated Gradient Optimization


May 2019: We will be discussing how chemists use scouting gradients to evaluate reactions and compound purity. These scouting gradients can be used to determine an efficient focused gradient for the desired compound. Topics covered will include techniques to create purification methods from focused gradients, and we will describe a new method allowing calculation of a focused gradient from a scouting run.

Speaker: Jack Silver, Application Chemist​

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Chromatography Webinar  

ACCQPrep HP150 Introduction

April 2019: We introduce our newest product: the ACCQPrep HP150! This latest innovation in Preparative HPLC systems does not follow the traditional path of an analytical system, but rather is intuitive and eliminates the unnecessary and complex integration parameters found in many of the HPLC systems in today's market. Plus, the ACCQPrep HP150 can be customized to meet your high performance purification needs.

By the end of this webinar, you will learn:

  • What the ACCQPrep HP150 is and how it was designed with the ease of a Flash system in mind.
  • How our automation options can be used to increase unattended purification throughput.
  • What the variable options are for sample loading which were created to meet your sample volume needs.
  • How the Focused Gradient Generator can generate a focused gradient to purify your target compound.

Speaker: Ronald Lewis, Product Line Manager - Chromatography

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...  

Wh​at to Do When Things Go Wrong in Prep Chromatography

March 2019: In our chromatography webinar, we will focus basic troubleshooting methods that are applicable to all Prep Chromatography systems. We will also take a look at retention time variations and how to handle them. Plus, we will take a look at other possible errors, such as poor peak shape, split peaks, and ghost peaks.

Speaker: Jack Silver, Application Chemist

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...  

Tips and Techniques to Optomize ELSD and MS Based Purification

February 2019: In our Chromatography webinar, we will discuss the benefits of ELSD as an alternative detection method to UV. We will also provide example of several applications and classes of compounds where ELSD may be useful, and how to choose and change different ELSD experimental parameters. Plus we will explain the advantages of our integrated ELSD options for the ACCQPrep and NextGen Chromatography lines.

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Presentation Slides

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Introduction to Flash Chromatography

January 2019: This webinar focuses on a comparison of HPLC and Flash Chromatography. We will look at both similarities and differences of these two processes, cover how to transition from TLC or open column chromatography to flash, and the associated advantages of flash. Lab managers and bench chemists involved in organic synthesis, where milligrams to grams of material need purified, or who are new to or not currently using flash chromatography will benefit from information covered in this webinar.


Watch the Webinar

...  

Basics of Prep HPLC

December 2018: In our Chromatography webinar “Basics of Prep HPLC," we will discuss what Liquid Chromatography and HPLC are, the differences between analytical & prep, and the basic method development of isocratic vs. gradient.

Other important topics to be covered include: effects of buffering and buffer choice for purification; injection solvent effects and solvent choices; solvent grade for prep and solvent selection; column care; and common trouble shooting techniques.

Watch the Webinar

...  

Green Solvent Solutions for Flash Chromatography

November 2018: The NextGen series of systems are designed with "Green" chromatography in mind. Its methods offer faster separations with improved gradient profiles resulting in less solvent used. These savings decrease our environmental footprint while maximizing lab efficiency in both time and cost savings. New Features on the NextGen including baseline correction allows for greener, safer solvents not typically used in chromatography.

In this webinar, we will discuss green chemistry in the context of developing methods including importance of stationary phase choice, alternate green solvent choices, and getting things right the first time. Finally, we will show examples of some of the system features on the NextGen and how you can use them to minimize environmental impact while maximizing purification efficiency.

Watch the Webinar

...  

Purification Considerations for Peptides

October 2018: In this webinar, we will also explore the advantages of mass-directed peptide purification and using flash chromatography in the pre-purification of peptides.

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...  

Natural Product Purification

August 2018: Topics covered include: what to do before purification, “Wide-Polarity Range” chromatography, column screening using “Wide-Polarity Range” chromatography for method development, and specialty chromatography media for natural products including Sephadex, ion exchange, and polyamide resin. Although the topics discussed use automated chromatography systems, the techniques can be adapted to hand-packed columns. You will come away from this webinar with a better understanding of natural product purifications and how Teledyne ISCO can meet these needs.

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