CombiFlash® EZ PrepCombiFlash® EZ Prep

Streamline Flash and Preparative HPLC chromatography with a compact, easy-to-operate unit 

The CombiFlash EZ Prep system from Teledyne ISCO is a dual function purification system that enables the user to perform both Flash and Preparative (Prep) purifications on the same instrument. Eliminating the need for two separate systems, the EZ Prep system provides the flexibility to seamlessly switch between Flash and Prep HPLC modes without compromising performance.

The EZ Prep also comes equipped with Teledyne ISCO's PeakTrak® software, a comprehensive package which integrates all detector options for single-point control. Designed with simplicity and ease-of-use in mind, PeakTrak allows even the most novice users to begin purifying samples within minutes.



CombiFlash® EZ Prep & NextGen Normal Phase Reverse Phase Flash ChangeoverApp Note
Enhanced Purification of Capsaicins with the CombiFlash EZ Prep App NoteApp Note
EZ Prep BrochureBrochure
CombiFlash EZ Prep DatasheetDatasheet
CombiFlash EZ Prep Injection Valve Rotor Replacement InstructionsInstruction Sheet
EZ Prep System Verification Instruction SheetInstruction Sheet
EZ Prep Test Mix Instruction SheetInstruction Sheet
CombiFlash EZ Prep Quick Start GuideQuick Start Guide
Chromatography Equipment Installation and Operation ChecklistTechnical Note
CombiFlash EZ Prep Installation Requirements Technical NoteTechnical Note
CombiFlash EZ Prep Phase Change Technical NoteTechnical Note
Networking Guidelines For Combiflash Products Technical NoteTechnical Note
CombiFlash User Manual (Excluding Torrent)User Manual
EZ Prep Automation User ManualUser Manual


​​​Co​mbiFlash® EZ Prep Specifications

Flow Rate Range​ 5 - 200 mL/min (Flash & Prep)​
​Pump Prime ​Self-priming
​​Maximum Pressure (Flash operation) ​​200 psi (13.8 bar)
​Maximum Pressure (Prep operation) ​​3,500 psi (240 bar)
​​UV and UV-Vis Detection ​​UV 200-400 nm (standard); UV-Vis 200-800 nm (optional)
​​ELSD Detection ​​Built-in ELSD detector compatible with UV or UV-Vis
​Mass Spectrometer ​Three models with mass ranges of 10-1,200 and 10-2,000 Da
​Number of Solvents ​Binary gradient between any two of four solvents
​Programmable gradients ​Linear, step, isocratic
​Sample introduction (Flash) ​Solid or liquid load
​Sample introduction (Prep) ​Variable volume liquid load (5mL loop standard)
​User Interface ​10.4 in touchscreen (26.4 cm)
​Fraction Collector ​Internal
​Dimensions ​ ​​​26.8 x 16.9 x 17 in (68 x 43 x 43.2 cm)

​For a full list of product specifications, see the datasheet.



When you purchase instruments from Teledyne ISCO, you not only receive innovative, high quality products, you also receive excellent customer service and product support. Your initial purchase is only the beginning of Teledyne ISCO's ongoing commitment to their customers.


Standard Features

  • Up to 3500 psi (240 bar) and 200 mL/min
  • Run Prep ​HPLC columns up to 50 mm in diameter (including 5 µm particle diameter)
  • Flash purification for 10 mg to 33 g followed by final compound purification on high-performance columns
  • UV, UV-Vis, ELSD, and MS detection options available
  • Switch between normal and reverse phase solvents

Liquid Chromatography Compatible with Automation Modules

  • Use the AutoInjector Module to make multiple purification runs on the​ same sample
  • Use the AutoSampler Module if you have several different samples to purify which may require multiple injections and different chromatographic conditions
  • Use the Column Selector Module to automatically switch to the next column required for your purification


Compatible with PurIon Mass Spectrometer

  • Add mass directed fractionation to your purification
  • Use with Teledyne ISCO's PeakTrak software for single point control of all mass spectrometer parameters
  • Choose from three models to meet the needs of your application​