ACCQPrep ​HP150

High Pressure Preparative Liquid Chromatography System

The Teledyne ISCO ACCQPrep HP150 was developed and designed with the ease of a Flash system in mind. It does not follow the traditional path of an analytical system, but rather this system has be​en designed to be intuitive and easy-to-use.

The ACCQPrep HP150 eliminates the unnecessary and complex integration parameters found in many of the HPLC systems in today's market. Our PeakTrak® software, which currently drives our CombiFlash® product line, is the basis for controlling the ACCQPrep HP150. By using this software, the need for a standalone PC is eliminated. This results in a smaller, more compact unit with an integrated touch screen interface.

Enjoy the confidence associated with Teledyne ISCO's active solvent and waste level monitoring which reduces the risk of solvent spills. In addition, all sample and collection racks are RFID coded eliminating the potential of missed tubes.

An exciting feature of the ACCQPrep HP150 is the Focus Gradient Generator. When activated, the user is prompted to run a preset scouting gradient then they select the target peak for purification and the focused gradient is automatically programmed into the system.​


​Standard Features

  • ​Flow rates from 1 to 150 mL/min allow development of Prep methods directly on the system without the need for pump head changes
  • Operating pressure up to 6000 psi
  • Choice of UV or UV-Vis plus ELSD and MS options

AS-AutoSampler-Groupt-1-Web.pngCompatible with AutoSamplers (AS 2x2 and AS 4x2)​

  • The two rack AS 2x2 and four rack AS 4x2 sampler options allow different chromatographic conditions to be applied to a variety of different samples and doubles or triples the fraction collection capabilities of the base system

Compatible with PurIon Mass Spectrometer

  • Add mass directed fractionation to your purification
  • Use with Teledyne ISCO's PeakTrak software for single point control of all mass spectrometer parameters
  • Choose from three models to meet the needs of your application

Accessories for Everyday Simplicity

Waste-Collection-Switching-Valve-Web.pngWaste Collection Switching Valve

Interfaces with AS 2x2 and AS 4x2. Directs waste from up to 12 samples into separate waste reservoirs. Ideal for open access to separate individual sample wastes. Requires presence of either the AS 2x2 or AS 4x2.

Third Solvent Modifier Pump

Controlled via PeakTrak and provides delivery of a third solvent at a fixed percentage during the purification.

Large Volume Sample Load Pump 


Perfect for peptides and natural applications dilute samples. Inject volumes of samples greater than 10 mL directly onto the column bypassing the injection loop. Pump control is integrated with PeakTrak.

RediSep Prep HPLC Columns 


Maximize Your Preparative HPLC Performance When you need the highest purity compound, your first choice should be to equip your ACCQPrep HP150 with RediSep Prep ​columns. Teledyne ISCO has built a quality reputation on the high performance of our flash purification columns. RediSep Prep columns are specifically designed for high performance liquid chromatography (Prep HPLC).​

Solvent Select Valve 

Easily change your chromatographic selectivity by changing to a different solvent system. The 3 x 2 solvent modifier allows any combination of 3 different A solvents with 3 different B solvents. 

Column Select Valve 

Change between up to 4 different installed columns with the CSV-4 module. Fully integrated automation with PeakTrak makes changing stationary phases or sizes a breeze.​



​​​​​ACCQ​Prep HP 150

​Flow Rate Range ​1 - 150 mL/min
​Pressure Limit ​up to 6000 psi (400 bar) Lower pressure limits user defined
​UV and UV-Vis Detection ​​Variable UV 200 - 400 nm standard, Variable UV-Vis 200 - 800 nm option
​ELSD Detection ​Integrated Option that can be combined with either UV or UV-Vis
​Number of Solvents ​​Binary gradient. 2 solvent std.  2x3 solvents optional
​Gradient Formation
​High Pressure
​Programmable gradients ​Linear, step, isocratic
​Gradient Linearity ​+/- 1%
​Sample Introduction ​Variable volume liquid load (5mL loop standard)
​User Interface ​15 in touchscreen
​Fraction Collector ​Internal
​Dimensions​ ​27.5 x 14.0 x 20.0 in (69.9 x 35.6 x 50.8 cm) (H x W x D)
84.5 pounds (38.2 kg)
​Dimensions AS 2x2 Autosampler Module ​​18.9 x 14.0 x 19.3 in (48.0 x 35.6 x 49.0 cm)​ (H x W x D)
31.1 lbs (14.1 kg)
​Dimensions AS 4x2 Autosampler Module ​27.5 x 23 x 22 in (69.9 x 58.4 x 55.9 cm)​ (H x W x D)
42.2 lbs (19.1 kg)

For a full list of product specifications, see the datasheet.




ACCQPrepSampleQueueGenerator1-710/12/2020 9:20 AM
Chiral Purifications App NoteApp Note12/10/2020 8:25 AM
Effects of Reverse Phase Chain Length on Peptide PurificationApp Note3/21/2018 3:30 PM
Focused Gradients, pH Control and Ionizable Compounds App NoteApp Note12/17/2020 5:29 PM
Generate Flash Focused Gradients at Lightning SpeedApp Note7/7/2021 10:04 AM
HPLC to FlashApp Note4/5/2021 11:08 AM
Purification of a Peptide ACE Inhibitor App NoteApp Note5/31/2017 7:36 AM
ACCQPrep HP150 BrochureBrochure2/20/2020 11:18 AM
Optimized Peptide PurificationBrochure7/10/2020 9:37 AM
ACCQPrep HP150 DatasheetDatasheet10/21/2020 9:14 AM
AutoSampler ACCQPrep DatasheetDatasheet12/10/2020 2:37 PM
ACCQPrep HP150 Installation GuideInstallation Guide8/18/2020 8:56 AM
ACCQPrep Column Selector Instruction SheetInstruction Sheet7/20/2017 12:14 PM
ACCQPrep HP150 Large Sample Load Pump Installation InstructionsInstruction Sheet5/29/2020 12:04 PM
ACCQPrep HP150 Third Solvent Modifier Pump InstructionsInstruction Sheet1/10/2020 10:20 AM
ACCQPrep HP150 Waste Collection Switching Valve InstructionsInstruction Sheet1/10/2020 10:28 AM
ACCQPrep Injection Valve Rotor ReplacementInstruction Sheet1/8/2018 4:00 PM
ACCQPrep Preventative Maintenance Instruction SheetInstruction Sheet11/18/2021 10:53 AM
ACCQPrep System Verification InstructionsInstruction Sheet10/11/2021 8:40 AM
ELSD Air Pump Instruction SheetInstruction Sheet8/2/2017 3:06 PM
Installing the ACCQPrep AI 5 AutoInjector Instruction SheetInstruction Sheet3/7/2018 1:29 PM
A Method to Save Time and Solvents Generating Purification Methods from Scouting GradientsPoster7/2/2019 12:34 PM
A New Way to Calculate Preparative GradientsPoster6/24/2022 1:18 PM
Easy Preparative Supercritical Fluid Chromatography Method Development-August 2021Poster8/30/2021 9:07 AM
Effects of Mobile Phase Solvents on Calculated Gradients-June 2021Poster8/30/2021 9:06 AM
Fall ACS 2017 Flow Chemistry PosterPoster9/1/2017 11:39 AM
Fall ACS 2017 Pore Size PosterPoster9/1/2017 11:39 AM
On-Column Dilution A Technique to Load Samples Dissolved in DMSOPoster7/2/2019 12:36 PM
Time-On-Target Easy Method Development for Reverse Phase Preparative ChromatographyPoster7/2/2019 12:38 PM
ACCQPrep Choosing the Correct RotorsTechnical Note5/26/2021 1:53 PM
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When you purchase instruments from Teledyne ISCO, you not only receive innovative, high quality products, you also receive excellent customer service and product support. Your initial purchase is only the beginning of Teledyne ISCO's ongoing commitment to their customers.