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​A colle​ction of articles sharing insights into faster, more efficient, and higher resolution chromatography.​​​

How Much Money Is Really Being Saved (or Lost) by Reusing Silica Flash Columns?

June 2, 2021

In our testing of the impact of strong solvents on the reproducibility of runs on analytical HPLC silica columns[1] we found a significant amount of wash is required for the column to behave as it did prior to first running a strong solvent on it. Surprised by how much solvent was needed, a conversation began among those of us in the Applications lab regarding this same effect on flash silica columns and the true cost of trying to reuse them.

How can you keep your ELSD performing optimally?​

May 7, 2021

One of the unique offerings for Teledyne ISCO flash prep and chromatography systems, including CombiFlash NextGen, EZ Prep and ACCQPrep, is the ability to add an internal evaporative light scattering detector (ELSD) without increasing the footprint of the instrument. ELSD is a great secondary detection method for compounds lacking UV chromophores. Our ELSD customers really like this feature and one question they often ask is, how do we keep the ELSD performing like new?​

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Do you really want to switch solvent systems on RediSep Prep HPLC Silica columns?


March 11, 2021

Normal phase separations using silica columns are common in flash separations, but the columns are traditionally one-time use and are used with a single solvent system.



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​​Rapidly Create Focused Gradient Methods for Prep LC from Analytical Scouting Runs

January 25, 2021

Which standard operating procedure in a preparative chromatography lab is more efficient: routinely running generic full-range gradients to purify mixtures, or taking the extra time and trouble to develop focused gradient methods?

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