CombiFlash® NextGen 300CombiFlash NextFen 300

Customizable for Your Application

The CombiFlash NextGen 300 is configurable to your needs. Like the CombiFlash NextGen 300+, active solvent and waste level sensing, along with column air purge, is standard. The system is designed for liquid injections, operating at up to 150 psi (10 bar). If needed, add the solid load injection valve (increases the operating pressure limit to 300 psi (20bar)) and increase the system's versatility.  Similarly, RFID rack and column read can be added if desired. You determine what your needs are; don’t invest in unused or unwanted features.​


CombiFlash NextGen Quick Start Guide.pdfCombiFlash NextGen Quick Start GuideQuick Start Guide
CombiFlash NextGen User Manual.pdfCombiFlash NextGen User ManualUser Manual
CombiFlash Pump Seal Replacement Instructions.pdfCombiFlash Pump Seal Replacement InstructionsInstruction Sheet
NextGen 300 Pump Greasing Instructions.pdfNextGen 300 Pump Greasing InstructionsInstruction Sheet
CombiFlash NextGen Safety Sheet.pdfCombiFlash NextGen Safety SheetInstruction Sheet
CombiFlash NextGen 300 Datasheet.pdfCombiFlash NextGen 300 DatasheetDatasheet
CombiFlash System Verification Instructions.pdfCombiFlash System Verification InstructionsInstruction Sheet
CombiFlash NextGen Brochure.pdfCombiFlash NextGen BrochureBrochure


When you purchase instruments from Teledyne ISCO, you not only receive innovative, high quality products, you also receive excellent customer service and product support. Your initial purchase is only the beginning of Teledyne ISCO's ongoing commitment to their customers.


​CombiFlash NextGen 300

​Flow Rate Range
​1 - 300 mL/min
​Pressure Limit

​300  psi (20 bar) with injection valve

150 psi (10 bar) without injection valve

​Column Sizes
​4 - 750 g
Sample Size ​10 mg - 30 g
​User Interface

​12 in touchscreen (30.5 cm)

15 in touchscreen (38.1 cm)

​Dimensions (H x W x D) ​26 x 14.1 x 17 in (66 x 36 x 43 cm)​

​For a full list of product specifications, see the datasheet.




  • Straightforward
    • Complete control on one screen
  • Compact
    •  Designed to take up minimal lab space
  • Flexible
    •  Configure to meet your specific needs
  • Faster
    •  New default methods speed up the flow without sacrificing performance
  • Greener
    •  Conserve solvent with optimized gradient


Standard Features

  • Flow rates from 1 to 300 mL/min
  • Operating pressure up to 150 psi (10 bar) Can be upgraded to 300 psi (20 bar)
  • Choice of UV, UV-Vis ELSD, or MS options
  • Customizable to meet your application needs
  • Active solvent and waste level sensing
  • Air purge​​
  • TUV Certified​​